Bijna fatale persisterende anion en osmolal gap acidose ten gevolge van massief GHB/ethanol intoxicatie: een case report
Samenvatting
We report a case of an ethanol and massive gamma-butyrolactone (GBL) intoxication, the precursor of the recreational
drug gamma-hydroxybutyric acid (GHB), resulting in life-threatening metabolic acidosis (pH 6.5) with a highly increased
anion- and osmolal gap. Rapid analysis using gas chromatography revealed a GHB plasma concentration of 4400 mg/L, far
above the upper limit concentration of 1000 mg/L found in adult fatalities attributed to GBL. Full recovery was established
following supportive treatment including haemodialysis. This is the first report of a combined ethanol/GBL
intoxication as a cause of high serum anion- and osmolal-gap metabolic acidosis
Onderzoekspopulatie
GHB en alcohol intoxicatie
Output
Heytens L, Neels H, Van Regenmortel N, van den Brink W, Henckes M, Schouwers S, Dockx G, Crunelle CL. Near-fatal persistent anion and osmolal gap acidosis due to massive gamma-butyrolactone/ethanol intoxication: a case report. Ann Clin Biochem. 2015 Mar;52(Pt 2):283-7.
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Einddatum 01/01/2015
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Datum laatste wijziging: 14/08/2017
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